CD3<sup>+</sup>CD294<sup>+</sup>T cells of the type 2 immune response: their role in allergic inflammation

T lymphocytes type 2 immune response protect against helminths and toxins, also contribute to the development of allergic inflammation. One most specific cell surface markers is CRTH2 molecule (CD294), which an activating receptor for prostaglandin D2. The CD3 + CD294 population negligible in peripheral blood healthy individuals; increase occurs patients with diseases autoimmune nature response. aim study was quantitative functional characteristics ? rhinoconjunctival symptoms (n = 248) drug hypersensitivity 184). In 68 elevated extremely high number cells, a detailed phenotype this characterized by flow cytometry activity studied relation production interleukin 4 interferon ? using enzyme immunoassay. control group consisted 34 volunteers. relative cells significantly higher – 1.6% 1.2% compared 1.0%. Elevated (1.6-3.6%) (>3.6%) were more frequently detected hypersensitivity. both groups, observed severe damage skin. CD45RA-CD3 CD2 CD5 CD7 CD27 CD28 CD57 - CCR7 determined, corresponds effector memory lymphocytes. With moderately increased amount population, usually represented helpers 2. A pronounced due cytotoxic Regardless predominance helper or revealed spontaneous at normal level interferon. An expression contributes development, maintenance exacerbation inflammation participation IgEdependent IgE-independent mechanisms. should be determined as additional parameter assessing presence sensitization basophil activation test reactions. use laboratory biomarker assess dominant will make it possible personalize therapy examined patients. Identification deviations indicators from average values influence tactics patient management.